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Suzuki coupling reaction for the solid-phase preparation of 5-substituted nicotinic acid derivatives |
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| Authors: | Joan-Carles Fernà ndez,Laia Solé -Feu,Natalia de la Figuera,Fernando Albericio |
| Affiliation: | a Almirall Prodesfarma-Barcelona Science Park Unit, Barcelona Science Park, Josep Samitier 1, 08028 Barcelona, Spain b Research Center, Almirall Prodesfarma, Cardener 68-74, 08024 Barcelona, Spain c Barcelona Biomedical Research Institute, Barcelona Science Park, Josep Samitier 1, 08028 Barcelona, Spain |
| Abstract: | The application of the Suzuki coupling reaction to the preparation of small combinatorial libraries using 5-bromonicotinic acid as a scaffold onto three different types of solid support (Wang, Rink, and BAL resin) is described. |
| Keywords: | Combinatorial chemistry Wang resin Rink resin Bal resin 5-Bromonicotinic acid Suzuki coupling Solid-phase organic synthesis |
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