A direct method for the synthesis of nucleoside 5′-methylenebis(phosphonate)s from nucleosides |
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| Authors: | Marcin Kalek |
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| Institution: | Department of Biophysics, Experimental Physics Institute, Warsaw University, Zwirki i Wigury 93, 02-089 Warsaw, Poland |
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| Abstract: | An efficient method for the preparation of nucleoside 5′-methylenebis(phosphonate)s has been developed. Unprotected nucleosides are phosphonylated directly with methylenebis(phosphonic dichloride). Reaction conditions were optimized to prevent side product formation. |
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| Keywords: | Nucleosides Nucleotides Bisphosphonates Synthesis |
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