Efficient total synthesis of (+)-curcuphenol via asymmetric organocatalysis |
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Authors: | Sung-Gon Kim Jaehak Kim Heejung Jung |
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Affiliation: | Medicinal Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong-gu, Daejeon 305-600, Republic of Korea |
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Abstract: | The catalytic enantioselective synthesis of (+)-curcuphenol is described herein. This approach involves the use of an organocatalytic alkylation of m-anisidine, a diazotation/Sandmeyer reaction of the amine and a Negishi-type coupling with dimethylzinc. This versatile strategy allows for the rapid synthesis of other members of this class of natural products. |
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Keywords: | Curcuphenol Total synthesis Organocatalysis |
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