Current-induced magnetic resonance phase imaging |
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Authors: | Bodurka J Jesmanowicz A Hyde J S Xu H Estkowski L Li S J |
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Affiliation: | Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA. |
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Abstract: | Electric current-induced phase alternations have been imaged by fast magnetic resonance image (MRI) technology. We measured the magnetic resonance phase images induced by pulsed current stimulation from a phantom and detected its sensitivity. The pulsed current-induced phase image demonstrated the feasibility to detect phase changes of the proton magnetic resonance signal that could mimic neuronal firing. At the present experimental setting, a magnetic field strength change of 1.7 +/- 0.3 nT can be detected. We also calculated the averaged value of the magnetic flux density BT parallel to B0 produced by electric current I inside the voxel as a function of the wire position. The results of the calculation were consistent with our observation that for the same experimental setting the current-induced phase change could vary with location of the wire inside the voxel. We discuss our findings in terms of possible direct MRI detection of neuronal activity. |
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