Osmotic and activity coefficients of aqueous bile salt solutions at 25, 37, and 45°C |
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Authors: | Patrick Carpenter Siegfried Lindenbaum |
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Institution: | (1) Department of Pharmaceutical Chemistry, McCollum Laboratories, University of Kansas, 66044 Lawrence, Kansas;(2) Present address: Wyeth Laboratories, Inc., Box 8299, 19101 Philadelphia, Pennsylvania |
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Abstract: | Osmotic coefficients measured by vapor pressure osmometry are reported for aqueous bile salt solutions at 25, 37, and 45°C. Solute activities decrease rapidly with increasing concentration due to premicellar association and micelle formation. In all cases, activities of the dihydroxy bile salts are lower than those of the trihydroxy bile salts. Osmotic coefficients and activity coefficients increase with increasing temperature. It is suggested that hydrophobic forces contribute substantially to the stability of primary bile salt aggregates and micelles. |
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Keywords: | Osmotic coefficients activity coefficients bile salts sodium cholate sodium deoxycholate sodium chenodeoxycholate sodium glycocholate sodium glycochenodeoxycholate sodium glycodeoxycholate sodium taurocholate sodium taurodeoxycholate |
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