| Synthesis and antitumor activity of a group of diosgenyl glycosides |
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| 作者姓名： | Shu Jie Hou Chuan Chun Zou Liang Zhou Peng Xu De Quan Yu Ping Sheng Lei |
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| 作者单位： | Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education,Institute of Materia Medica, Peking Union Medical College ＆ Chinese Academy of Medical Science,Beijing 100050, China |
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| 摘 要： | Using orthogonal protection-deprotection glycosylation strategy, a series of diosgenyl glycosides with same of monosaccharides component but different in sequence were synthesized. The antitumor activity in vitro of synthesized diosgenyl glycosides was evaluated by standard MTT assay. It was observed that diosgenyl glycosides with a rhamnopyranosyl at C2′ of glucopyranosyl residue show potent antitumor activity in vitro.
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| 关 键 词： | 配醣苷 合成 抗癌活性 糖基化 细胞毒性 |
| 修稿时间： | 2007-03-01 |
Synthesis and antitumor activity of a group of diosgenyl glycosides |
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| Shu Jie Hou Chuan Chun Zou Liang Zhou Peng Xu De Quan Yu Ping Sheng Lei.Synthesis and antitumor activity of a group of diosgenyl glycosides[J].Chinese Chemical Letters,2007,18(7):769-772. |
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| Authors: | Shu Jie Hou Chuan Chun Zou Liang Zhou Peng Xu De Quan Yu Ping Sheng Lei |
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| Institution: | Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100050, China |
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| Abstract: | Using orthogonal
protection-deprotection glycosylation strategy, a series of diosgenyl glycosides with same
of monosaccharides component but different in sequence were synthesized. The antitumor
activity in vitro of synthesized diosgenyl glycosides was evaluated by standard MTT assay.
It was observed that diosgenyl glycosides with a rhamnopyranosyl at C'2 of glucopyranosyl
residue show potent antitumor activity in vitro.(C) 2007 Ping Sheng Lei. Published by
Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
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| Keywords: | Diosgenyl glycosides Glycosylation Cytotoxicity |
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