Concise total synthesis of (-)-spongotine A |
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| Authors: | Murai Kenichi Morishita Maiko Nakatani Ryo Kubo Ozora Fujioka Hiromichi Kita Yasuyuki |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-Oka, Suita, Osaka, Japan. |
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| Abstract: | The first asymmetric total synthesis of spongotine A is described. The oxidative synthesis of the imidazoline/ketone unit from keto aldehyde and diamine is a key step in this synthesis. The absolute stereochemistry of the asymmetric center of natural spongotine A is revealed as the (S)-configuration. |
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