Synthesis of a dendritic estrogen cluster:A potential tool for studies of nuclear versus extranuclear pathways of estrogen actions |
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| Authors: | Jian Chena Hu Zhengb Yan Songa Yu Feng Liangb Qing Rong Qib. a Functional FoodDrug Laboratory |
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| Affiliation: | Functional Food (Drug) Laboratory, Institute of Agro-product Processing Science and Technology, Sichuan Academy of Agricultural Science, Chengdu 610066, China ; Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
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| Abstract: | A novel estrogen dendrimer has been synthesized through a combination of divergent and convergent approaches in 9 practical steps and in good yields. It was characterized and confirmed by elemental analysis, FT-IR, MS, 1H NMR, 13C NMR. The dendrimer contains 16 estrone units and is potentially a useful tool for the studies of estrogen actions. |
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| Keywords: | Estrogen dendrimer Synthesis Nuclear and extranuclear Receptor |
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