Use of N-N bond stereodynamics in ring-closing metathesis to form medium-sized rings and macrocycles |
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Authors: | Kim Yi Jin Lee Daesung |
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Institution: | Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. |
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Abstract: | A unique strategy based on double ring-closing metathesis for the formation of a 14-membered macrocyclic enamide has been developed. This strategy hinges upon the well-known stereodynamic and conformational behavior of N-substituted diacylhydrazines, which promotes an effective ring-closing metathesis of hydrazine-derived dienes and enynes to form 8- to 14-membered rings. |
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