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| 对乙酰氨基酚氯美扎酮分散片溶出度研究 | |
| 引用本文： | 王淑君,姚家元,郭慧,孟祥军.对乙酰氨基酚氯美扎酮分散片溶出度研究[J].光谱实验室,2010,27(4):1411-1414. |
| 作者姓名： | 王淑君 姚家元 郭慧 孟祥军 |
| 作者单位： | 1. 沈阳一天生物制药有限公司,沈阳市经济技术开发区大路7甲3号,110027 2. 辽宁省沈阳市国有控股集团有限公司,沈阳市和平区市府大路106号,110002 3. 沈阳国大天益堂药房连锁有限公司,沈阳市铁西区兴华南街46号惠和大厦四楼,110021 4. 沈阳医学院,沈阳市皇姑区黄河北大街146号,110034 |
| 摘 要： | 采用高效液相色谱法测定对乙酰氨基酚氯美扎酮分散片溶出度。以稀盐酸24mL加水至1000mL为溶媒,转速为100r.min-1,取样时间为15min,在227nm波长处测定其溶出度。对乙酰氨基酚平均回收率为100.6%,RSD=0.59%;氯美扎酮平均回收率为100.6%,RSD=0.86%。3批样品15min溶出度均在90%以上,且溶出均一。本法简便、准确、可靠,可用于该制剂的溶出度测定。 |
| 关 键 词： | 对乙酰氨基酚氯美扎酮分散片 溶出度 高效液相色谱法 |
Study on Dissolution of Paracetamol and Chlormezanone in Dispersble Tablets |
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| WANG Sha-Jun,YAO Jia-Yuan,Guo Hui,MENG Xiang-Jun.Study on Dissolution of Paracetamol and Chlormezanone in Dispersble Tablets[J].Chinese Journal of Spectroscopy Laboratory,2010,27(4):1411-1414. | |
| Authors: | WANG Sha-Jun YAO Jia-Yuan Guo Hui MENG Xiang-Jun |
| Institution: | WANG Shu-Jun YAO Jia-Yuan a GUO Hui b MENG Xiang-Jun c(Shengyang Yitian Biological Pharmaceutical Company Limited,Shenyang 110027,P.R.China)a(Shenyang City,the Sstate-Owned Holding Group Ltd.,Shengyang 110002 ,P.R.China)b(Shenyang City Guo Da Tian Yi Tang Pharmacy Chain Ltd.,Shenyang 110021,P.R.China)c(Shenyang Medical College Liaoning,Shenyang 110034,P.R.China) |
| Abstract: | The dissolution of paracetamol and chlormezanone in dispersble tablets were determined by HPLC with dilute hydrochloride acid 24—1000mL as solvent at a rotation speed of 100r·min-1.The sampling time was 15min and the detection wavelength was at 227nm.The average recovery of chlormezanone was 100.6% with RSD=0.59%,and the average recovery of chlormezanone was 100.6% with RSD=0.86%.The dissolution of three batches of samples were all above 90%.The method is simple,accurate ,reliable,and was used for the determination of dissolution of paracetamol and chlormezanone dispersble tablets. |
| Keywords: | Paracetamol and Chlormezanone Dispersble Tablets Dissolution HPLC |
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