Diels-Alder reactions of 3-(1H-tetrazol-5-yl)-nitrosoalkenes: synthesis of functionalized 5-(substituted)-1H-tetrazoles |
| |
Authors: | Susana M.M. LopesFrancisco Palacios,Amé rico Lemos |
| |
Affiliation: | a Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal b Department of Organic Chemistry I, Faculty of Pharmacy, University of the Basque Country, Apartado 450, 01080 Vitoria, Spain c CIQA, FCT, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal |
| |
Abstract: | A general route to 1,2-oxazines and open chain oximes bearing a 1H-tetrazolyl substituent via Diels-Alder reaction of 3-(tetrazol-5-yl)-nitrosoalkenes is reported. It was also demonstrated that reduction of these adducts followed by deprotection of the tetrazolyl group give 5-(1-aminoalkyl)-1H-tetrazoles, α-amino acid analogues. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|