Nickel (Ⅱ) Catalyzed 1, 4- Addition Reactions of Functionalized Orgnaozinc Reagents with Enones

Organozinc reagent is one of the earliest organometallic compounds prepared. Investigation of its application in organic synthesis had been completed before 1880.However, it was replaced at the turn of the century by the more reactive organomagnesiun reagent except Reformatsky reaction because of its low reactivity toward most organic electrophiles. In 1978, Mukaiyama first reported that Et2Zn reacted with benzaldehyde in the presence of aminoalcohol to give 1, 2-addition product in excellent yield. Pursuant to this report, a lot of papers about the reaction of organozinc reagent with organic electrophiles have been appeared. However, most of the researches focused on dialkylzinc regents, few papers on study of organozinc halides had appeared until 1988.