| DNA双链断裂产额的新算法 |
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| 引用本文： | 周光明,李文建,高清祥,卫增泉.DNA双链断裂产额的新算法[J].原子核物理评论,2003,20(1):52-54. |
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| 作者姓名： | 周光明 李文建 高清祥 卫增泉 |
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| 作者单位： | 1 中国科学院近代物理研究所; 甘肃兰州730000;2 兰州大学生命科学学院; 甘肃兰州730000; |
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| 基金项目： | 中国科学院西部之光课题(XB980604)~~ |
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| 摘 要： | DNA双链断裂(DSB)的定量分析是高传能线密度辐射生物学效应机理研究的重要手段.从实际应用出发,推导了一个新的计算公式———平均分子量法.该法不探究DSB片段的具体分布模式,实际操作中却又包含了片段的含量和分布;而且形式简单、操作简便,尤其适合于荧光扫描数据. Quantitive analysis of DNA double strand break (DSB) is of importance for studying on the mechanisms of radiobiological effects induced by high linear energy transfer(LET) irradiation. For the practical use, one new calculating formula named the method of average molecular weight is deducted. In this method, the factual distribution of DSB fragments is not considered, but actually, the content and distribution of DSB fragments are included. Totally, this method is simple in shape and easy to use, esp...
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| 关 键 词： | DNA双链断裂 高传能线密度辐照 生物学效应 计算方法 |
| 文章编号： | 1007-4627(2003)01-0052-03 |
| 收稿时间： | 1900-01-01 |
| 修稿时间： | 2002年9月17日 |
A New Method for Calculating Yield of DNA Double-strand Breaks |
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| ZHOU Guang-ming,LI Wen-jian,GAO Qing-xiang,WEI Zeng-quan.A New Method for Calculating Yield of DNA Double-strand Breaks[J].Nuclear Physics Review,2003,20(1):52-54. |
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| Authors: | ZHOU Guang-ming LI Wen-jian GAO Qing-xiang WEI Zeng-quan |
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| Institution: | 1 Institute of Modern Physics; Chinese Academy of Sciences; Lanzhou 730000; China; 2 School of Life Science; Lanzhou University; China); |
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| Abstract: | Quantitive analysis of DNA double strand break (DSB) is of importance for studying on the mechanisms of radiobiological effects induced by high linear energy transfer(LET) irradiation. For the practical use, one new calculating formula named the method of average molecular weight is deducted. In this method, the factual distribution of DSB fragments is not considered, but actually, the content and distribution of DSB fragments are included. Totally, this method is simple in shape and easy to use, esp... |
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| Keywords: | DNA double-strand break high linear energy transfer irradiation biological effect calculating method |
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