| Synthesis of derivatives of imidazo[4,5-b]pyridine:Novel sulfur contained side chains for macrolide antibiotics |
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| 基金项目： | 国家自然科学基金，北京市自然科学基金 |
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| 摘 要： | Two series of novel derivatives of imidazo4,5-b]pyridine were synthesized.These compounds could be used as side chains of semisynthesised ketolide antibiotics.The side chains have free amine group which can attached to ketolide core.Macrolides with this kind of side chains will show obvious activities against erythromycin-resistant strains.The structure of the side chains was confirmed by ~1H,~(13)C NMR,MS,HMBC spectra.
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Synthesis of derivatives of imidazo [4,5-b] pyridine: Novel sulfur contained side chains for macrolide antibiotics |
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| Authors: | Lu Liu Peng Xu Liang Zhou Ping Sheng Lei |
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| Abstract: | Two series of novel derivatives of imidazo4,5-b]pyridine were synthesized. These compounds could be used as side chains ofsemisynthesised ketolide antibiotics. The side chains have free amine group which can attached to ketolide core. Macrolides withthis kind of side chains will show obvious activities against erythromycin-resistant strains. The structure of the side chains wasconfirmed by 1H, 13C NMR, MS, HMBC spectra. |
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| Keywords: | Macrolide Heterarylalkyl sulfur contained side chain Imidazo[4 5-b]pyddine Synthesis HMBC |
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