New copper complexes with N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide ligand |
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| Affiliation: | 1. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. V. I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation;3. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation;4. N. I. Pirogov Russian National Research Medical University, 117997 Moscow, Russian Federation |
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| Abstract: | Crystals of two copper complexes with N-(5,6-dihydro-4H- +1,3-thiazin-2-yl)benzamide were obtained and characterized by X-ray diffraction analysis. LETDI studies have shown that the composition of the complex is inhomogeneous, and the precipitated crystals can have different structures being of Cuii or Cui–Cuii types. The complexes are significantly more cytotoxic toward the leukemic Jurkat cell line than to healthy lymphocytes. |
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