Rapid alkenylation of quinoxalin-2(1H)-ones enabled by the sequential Mannich-type reaction and solar photocatalysis |
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Institution: | 1. College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China;2. College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China |
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Abstract: | Herein, a rapid alkenylation of quinoxalin-2(1H)-ones enabled by a combination of Mannich-type reaction and solar photocatalysis is demonstrated. A wide range of functional groups are compatible, affording the corresponding products in moderate-to-good yields. Control experiments illustrate that the in situ generated 1O2 plays a central role in this reaction. This green and efficient strategy provides a practical solution for the synthesis of potentially bioactive compounds that containing a 3,4-dihydroquinoxalin-2(1H)-one structure. |
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Keywords: | Alkenylation Methyl ketones Mannich-type reaction Solar photocatalysis |
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