Diaminodiacid bridge improves enzymatic and in vivo inhibitory activity of peptide CPI-1 against botulinum toxin serotype A |
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Institution: | Beijing Institute of Biotechnology, Beijing 100071, China |
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Abstract: | The replacement of the disulfide bridge of CPI-1, a peptide inhibitor of light chain of Botulinum toxin serotype A, with the thioether-containing and biscarba-containing diaminodiacid bridge leads to a significant decrease in the degradation by trypsin and increase in the detoxification activity in vivo, the addition of hydrophobic or positive amino acid at C-terminus of modified peptides further improves the inhibitory activity. |
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Keywords: | Botulinum neurotoxin serotype A Light chain inhibitor Peptide CPI-1 Diaminodiacid bridges Inhibitory activity |
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