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Synthesis of modified conformationally fixed tricarbocyanine dyes for conjugation with therapeutic agents |
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| Affiliation: | 1. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. Branch of M. M. Shemyakin–Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russian Federation;3. Russian Scientific Center of Roentgenoradiology, 117997 Moscow, Russian Federation;4. N. N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russian Federation |
| Abstract: | New β-alanine modified tricarbocyanines containing various substituents at quaternized nitrogen atoms were obtained. The peptide synthesis method has been utilized for further conjugation thus giving promising tricarbocyanines containing two sulfonate groups and total negative charge of the fluorophore. |
| Keywords: | fluorophores conjugates β-alanine cell-penetrating peptides tricarbocyanine dyes Fluorescent markers |
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