Assessing the performance of rotational spectroscopy in chiral analysis |
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Authors: | Sé rgio R. Domingos,Cristó bal Pé rez,Mark D. Marshall,Helen O. Leung,Melanie Schnell |
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Affiliation: | Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg Germany.; Department of Chemistry, Amherst College, P.O. Box 5000, Amherst Massachusetts 01002-5000 USA ; Institut für Physikalische Chemie, Christian-Albrechts-Universität zu Kiel, Max-Eyth-Str.1, 24118 Kiel Germany |
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Abstract: | The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abilities and challenges of two emergent techniques for chiral analysis based on rotational spectroscopy. For that, we will showcase the two methods (microwave 3-wave mixing and chiral tag rotational spectroscopy) while testing their performance to solve the absolute configuration and the enantiomeric excess of a blind sample containing a mixture of enantiomers of styrene oxide.Two rotational spectroscopy methods are challenged to solve the absolute configuration and enantiomeric excess of a chiral mixture of unknown composition. |
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