Thermodynamic models for determination of the solubility of dibenzothiophene in (methanol + acetonitrile) binary solvent mixtures |
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| Institution: | 1. State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, China;2. Taiyuan Qiaoyou Chemical Industrial Co. Ltd., Taiyuan 030025, China;1. Medicinal Chemistry Research Laboratories, Takeda Pharmaceutical Company Limited, 2-17-85, Juso-honmachi, Yodogawa-ku, Osaka 532-8686, Japan;2. CNS DDU, Takeda Pharmaceutical Company Limited, 2-17-85, Juso-honmachi, Yodogawa-ku, Osaka 532-8686, Japan;1. Department of General Surgery, Kartal Training Hospital, Istanbul, Turkey;2. Department of Transplantation, Kartal Training Hospital, Istanbul, Turkey;3. Bahcesehir University, Department of General Surgery, Istanbul, Turkey;4. Department of Biochemistry, Yuzuncu Yil University, Van, Turkey;5. Department of Chest Diseases, Yeniyuzyil University, Istanbul, Turkey;6. Department of Nephrology, Tekirdag State Hospital, Tekirdag, Turkey;7. Bahcesehir University, Department of Nephrology, Istanbul, Turkey;1. School of Chemical and Environmental Engineering, North University of China, Taiyuan 030051, Shanxi, China;2. National Key Laboratory of Applied Physics and Chemistry, Xi’an 710061, Shaanxi, China |
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| Abstract: | In this paper, we focused on solubility and solution thermodynamics of dibenzothiophene. By the gravimetric method, the solubility of dibenzothiophene was measured in (methanol + acetonitrile) binary solvent mixtures at temperatures from (278.15 to 333.15) K under atmosphere pressure. The solubility data were fitted using a modified Apelblat equation, a variant of the combined nearly ideal binary solvent/Redich–Kister (CNIBS/R–K) model and Jouyban–Acree model. Computational results showed that the modified Apelblat equation was superior to the other two equations. In addition, the thermodynamic properties of the solution process, including the Gibbs free energy, enthalpy, and entropy, were calculated by the van’t Hoff analysis. The experimental results showed that methanol could be used as effective anti-solvents in the crystallization process. |
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| Keywords: | Dibenzothiophene Apelblat equation CNIBS/R-K Jouyban–Acree model Van’t Hoff analysis |
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