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Determination and correlation of solubility of tylosin tartrate in alcohol mixtures
Institution:1. Department of Chemistry, University of Isfahan, Isfahan 81746-73441, Iran;2. Department of Chemistry, Sharif University of Technology, P.O. Box 11155-3516, Tehran, Iran
Abstract:Data on (solid + liquid) equilibrium of tylosin tartrate in {methanol + (ethanol, 1-propanol or 2-propanol)} solvents will provide essential support for industrial design and further theoretical studies. In this study, the solubility of tylosin tartrate in alcohol mixtures was measured over temperature range from (278.15 to 323.15) K under atmospheric pressure by a gravimetric method. From the experimental results, the solubility of tylosin tartrate in selected solvents noted above was found to increase with increasing temperature and mass fraction of methanol. The solubility data were correlated with the modified Apelblat equation, the λh equation and van’t Hoff equation. The results showed that the three equations agreed well with the experimental values, and that the modified Apelblat equation was more accurate than the λh equation and van’t Hoff equation. Further, the standard enthalpy, standard entropy and standard Gibbs free energy of solution of tylosin tartrate in mixed solvents were calculated according to solubility results, model parameters with modified Apelblat equation and van’t Hoff equation.
Keywords:Tylosin tartrate  Solubility  Determination  Correlation
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