Electrochemical oxidative decarboxylation and 1,2-aryl migration towards the synthesis of 1,2-diaryl ethers |
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| Authors: | Faxiang Bu Lijun Lu Xia Hu Shengchun Wang Heng Zhang Aiwen Lei |
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| Institution: | College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072 Hubei P. R. China.; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022 Jiangxi P. R. China |
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| Abstract: | Carboxylic acid compounds are important chemicals and are widely present in various natural products. They are not only nucleophiles, but also radical precursors. Classic transition-metal-catalyzed and photochemical decarboxylation have shown their excellent site selectivity in radical chemistry. However, electrochemical decarboxylation with a long history hasn''t got enough attention in recent years. In this work, the electrochemical oxidative decarboxylation and 1,2-aryl migration of 3,3-diarylpropionic acids have been introduced to construct C–O bonds with alcohols. Remarkably, this transformation can proceed smoothly without metal catalysts and external oxidants.Carboxylic acid compounds are important chemicals and are widely present in various natural products. The conversion of carboxylic acids into valuable compounds is a promising field. |
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