Measurement and correlation of solubility of 4-chloro-2,5-dimethoxynitrobenzene and 4-chloro-2,5-dimethoxyaniline in methanol,ethanol, xylene and toluene |
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| Institution: | 1. Nanotechnology Research Laboratory, Department of Physics, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia;2. Department of Physics, Faculty of Education at Al-Mahweet, Sana’a University, Al-Mahweet, Yemen;3. Department of Physics, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia;1. Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK;2. Chemical Crystallography, Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK;3. GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK;1. College of Materials Science and Engineering, Fuzhou University, Fuzhou 350116, PR China;2. College of Printing and Packing Engineering, Xi’an University of Technology, Xian 710048, PR China |
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| Abstract: | The solubility of 4-chloro-2,5-dimethoxynitrobenzene (CDMB) and 4-chloro-2,5-dimethoxyaniline (CDMA) in methanol, ethanol, xylene and toluene was measured over the temperatures range from (278 to 338) K by the dynamic method using a laser monitoring observation technique. The solubility in all solvents increased with temperature and the greatest solubility of both systems was obtained in toluene. The Wilson and the NRTL models were applied to correlate the experimental results. The root-mean-square deviations for the system of (CDMB + solvent) ranged from T = (0.11 to 0.34) K and (0.08 to 0.33) K calculated by the Wilson and the NRTL models, respectively, while for the system of (CDMA + solvent) the root-mean-square deviations ranged from T = (0.11 to 0.32) K and (0.14 to 0.33) K. The melting points and enthalpies of fusion of CDMA and CDMB were determined by differential scanning calorimetry (DSC). Toluene was found to be the preferred solvent for the reduction of CDMB to CDMA from the point of view of reaction and product separation |
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| Keywords: | 4-Chloro-2 5-dimethoxynitrobenzene 4-Chloro-2 5-dimethoxyaniline Solubility Wilson model NRTL model |
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