Relationship between physicochemical properties,lipophilicity parameters,and local anesthetic activity of dibasic esters of phenylcarbamic acid |
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| Authors: | I Malík E Sedlárová J Csöllei F Andriamainty J Čižmárik |
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| Institution: | (1) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, SK-832 32 Bratislava, Czechoslovakia;(2) Institute of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, CZ-612 42 Brno, Czechoslovakia |
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| Abstract: | The basic physicochemical properties, lipophilicity parameters of dibasic alkyloxy-substituted phenylcarbamic acids were estimated.
For the prepared set of compounds the experimentally obtained solubility, acidity, and lipophilicity parameters were correlated
with those computed using various computer programs based on the associative artificial neural network and fragmental methods.
The results of pharmacological evaluation were used as entry data for the complex correlations. |
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| Keywords: | phenylcarbamates acidity lipophilicity local anesthesia QSAR |
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