A flow injection chemiluminescence system for the determination of isoniazid |
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Authors: | Huang Y Zhang Z Zhang D Lv J |
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Institution: | Institute of Analytical Sciences, Southwest Normal University, Beibei, PR China. |
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Abstract: | A chemiluminescence (CL) flow system is described for the determination of isoniazid based on its enhancement on the chemiluminescence (CL) emission produced upon mixing a hexacyanoferrate(III) solution with an alkaline luminol solution. The system responds linearly to isoniazid concentration in the range 0-1 mg/L with a detection limit (3sigma) of 0.03 microg/L, relative standard deviation (RSD) of 1.2% for 0.1 mg/L isoniazid (n = 11). The system has been successfully applied to the determination of isoniazid in pharmaceutical preparations. |
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