Unexpected Reduction of Iminoquinone and Quinone Derivatives in Positive Electrospray Ionization Mass Spectrometry and Possible Mechanism Exploration |
| |
| Authors: | " target="_blank">Jiying Pei Cheng-Chih Hsu Ruijie Zhang Yinghui Wang Kefu Yu Guangming Huang |
| |
| Institution: | 1.School of Marine Sciences,Guangxi University,Nanning,People’s Republic of China;2.Department of Chemistry, School of Chemistry and Materials Science,University of Science and Technology of China (USTC),Hefei,People’s Republic of China;3.Department of Chemistry,National Taiwan University,Taipei,Taiwan |
| |
| Abstract: | Unexpected reduction of iminoquinone (IQ) and quinone derivatives was first reported during positive electrospray ionization mass spectrometry. Upon increasing spray voltage, the intensities of IQ and quinone derivatives decreased drastically, accompanying the increase of the intensities of the reduction products, amodiaquine (AQ) and phenol derivatives. To gain more insight into the mechanism of such reduction, we explored the experimental factors that are influential to corona discharge (CD). The results show that experimental parameters that favor severe CD, including metal spray emitter, using water as spray solvent, sheath gas with low dielectric strength (e.g., nitrogen), and shorter spray tip-to-mass spectrometer inlet distance, facilitated the reduction of IQ and quinone derivatives, implying that the reduction should be closely related to CD in the gas phase. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
