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Paper Spray Tandem Mass Spectrometry Based on Molecularly Imprinted Polymer Substrate for Cocaine Analysis in Oral Fluid |
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| Authors: | Ludmyla S Tavares Thays C Carvalho Wanderson Romão Boniek G Vaz Andréa R Chaves |
| Institution: | 1.Instituto de Química,Universidade Federal de Goiás,Goiania,Brazil;2.Departamento de Química,Universidade Federal do Espírito Santo,Vitória,Brazil;3.Instituto Nacional de Ciência e Tecnologia em Ciências Forenses,Porto Alegre,Brazil |
| Abstract: | This study proposes a new direct and fast method of analysis employing paper spray mass spectrometry (PS-MS). The paper used in the proposed method was modified with molecularly imprinted polymers (MIP) to create a specific site for cocaine analysis in oral fluid. MIP membrane was successfully synthetized and employed. The developed method showed to be linear in a concentration range from LOQ to 100 ng mL–1. The experimental value of LOQ obtained was 1 ng mL–1. The inter-day and intra-day precision and accuracy of the PS-MS method presented values lower than 15%. The total recoveries were also evaluated. The PS-MS method for the analysis of cocaine in oral fluid showed to be very promising and the validation parameters showed a good correlation with the literature. Graphical abstract ? |
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