Facile synthesis of substituted pyrrole-fused isocoumarins from ninhydrin |
| |
Authors: | Sudipta PathakAshis Kundu Animesh Pramanik |
| |
Institution: | Department of Chemistry, University of Calcutta, 92, A.P.C. Road, Kolkata 700 009, India |
| |
Abstract: | A simple and efficient procedure has been developed for the synthesis of substituted pyrrole-fused isocoumarins from easily available ninhydrin. The cyclic hemiaminal dihydroxy-indenopyrroles, the adducts of ninhydrin with enamines of acetylacetone, give pyrrole-fused isocoumarins upon heating in acidic medium. The process constitutes an interesting acid-catalyzed rearrangement to eight-membered lactams followed by intramolecular cyclization involving the amino and keto groups. |
| |
Keywords: | Ninhydrin Primary amine Acid-catalyzed reaction Pyrrole-fused isocoumarins |
本文献已被 ScienceDirect 等数据库收录! |