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A short microwave-assisted synthesis of tetrahydroisoquinolin-pyrrolopyridinones by a triple process: Ugi-3CR-aza Diels-Alder/S-oxidation/Pummerer |
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| Authors: | Alejandro Islas-Já comeEduardo Gonzá lez-Zamora,Rocí o Gá mez-Montañ o |
| Affiliation: | a Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina Iztapalapa, C.P. 09340, México D.F., Mexico b Departamento de Química, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, C.P. 36050, Guanajuato, Gto., Mexico |
| Abstract: | A series of tetrahydroisoquinolin-pyrrolopyridinones were prepared from an easily accessible aldehyde, a commercially available amine, a readily isolable isonitrile, and maleic anhydride via a triple process: Ugi-3CR-aza Diels-Alder/S-oxidation/Pummerer. The combination of a multicomponent Ugi-type reaction with other post-functionalization processes provides a powerful tool for the preparation of fused polyheterocyclic compounds. |
| Keywords: | Microwave-assisted synthesis Tetrahydroisoquinolin-pyrrolopyridinones Ugi-3CR Aza Diels-Alder cycloaddition S-oxidation Pummerer cyclization |
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