Chemiluminescence of chlorpromazine hydrochloride based on cerium(IV) oxidation sensitized by rhodamine 6G |
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Authors: | Huang Yuming Chen Zhaohui |
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Institution: | Department of Chemistry, Institute of Analytical Sciences, Southwest Normal University, Beibei, Chongqing 400715, People's Republic of China. |
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Abstract: | A new chemiluminescence (CL) method is proposed for the determination of chlorpromazine hydrochloride, a drug often used to treat the psychiatric patients suffering from clinical depression. The method is based on the reaction between studied drug and Ce(IV) in a nitric acid medium and measurement of the CL intensity produced by rhodamine 6G used as a sensitizer. In the optimum conditions, CL intensities are proportional to concentrations of the studied drug over the range 0-1x10(-5) g ml(-1) with a detection limit of 6.5x10(-9) g ml(-1). The relative standard deviation (R.S.D.) is 4.1% for 1.5x10(-6) g ml(-1) chlorpromazine hydrochloride (n=11). The method has been applied to the determination of studied drug in tablets and biological fluids with satisfactory results. |
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