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| Synthesis and Crystal Structure of 5,7-Dimethoxy-2-phenylquinolin-4-yl Phenyloxy （N-L-Alanine ethyl ester） Phosphoramidate | |
| 引用本文： | 袁金伟,陈晓岚,屈凌波,朱玉,黄小莹,赵玉芬. Synthesis and Crystal Structure of 5,7-Dimethoxy-2-phenylquinolin-4-yl Phenyloxy （N-L-Alanine ethyl ester） Phosphoramidate[J]. 结构化学, 2009, 28(4): 498-502 |
| 作者姓名： | 袁金伟 陈晓岚 屈凌波 朱玉 黄小莹 赵玉芬 |
| 作者单位： | YUAN Jin-Wei,CHEN Xiao-Lan,ZHU Yu,HUANG Xiao-Ying(Key Laboratory of Organic Chemistry and Chemical Biology of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou 450052,China);QU Ling-Bo(Key Laboratory of Organic Chemistry and Chemical Biology of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou 450052,China;Henan University of Technology,Zhengzhou,Henan Province 450052,China);ZHAO Yu-Fen(Key Laboratory of Organic Chemistry and Chemical Biology of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou 450052,China;Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology,Ministry of Education,Department of Chemistry,School of Life Sciences and Engineering,Tsinghua University,Beijing 100084,China) |
| 基金项目： | 国家自然科学基金,Hcnan Academic Foundation of Science and Technology |
| 摘 要： | 5,7-Dimethoxy-2-phenylquinolin-4-yl phenyloxy （N-L-alanine ethyl ester） phosphoramidate （C28H29N2O7P, Mr = 536.17） has been synthesized by a facial phosphorylated reaction, and its structure was determined by IR, NMR, HR MS and X-ray single-crystal diffraction. The crystal belongs to triclinic, space group P1^-, with a = 11.375（2）, b = 11.591（2）, c = 11.638（2） A^°, α= 109.46（3）, β= 104.58（3）, γ= 100.48（3）°, V = 1339.6（5）A^°^3, Z = 2, Dc = 1.330 g/cm^3,μ = 0.152 mm^-1, F（000） = 564, the final R = 0.0654 and wR = 0.1546. In the crystal structure, the title compound is constructed by a centrosymmetric dimmer unit composed of a pair of π-π stacking diastereoisomers. The compound has a noteworthy feature in the framework, and such units are linked by two equal intermolecular P=O…H-N hydrogen bonds. |
| 关 键 词： | 晶体结构 二甲氧基 丙氨酸 合成 乙酯 标题化合物 磷酸化反应 对映异构体 |
Synthesis and Crystal Structure of 5,7-Dimethoxy-2-phenylquinolin-4-yl Phenyloxy (N-L-Alanine ethyl ester) Phosphoramidate |
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| YUAN Jin-Wei,CHEN Xiao-Lan,QU Ling-Bo,ZHU Yu,HUANG Xiao-Ying,ZHAO Yu-Fen. Synthesis and Crystal Structure of 5,7-Dimethoxy-2-phenylquinolin-4-yl Phenyloxy (N-L-Alanine ethyl ester) Phosphoramidate[J]. Chinese Journal of Structural Chemistry, 2009, 28(4): 498-502 | |
| Authors: | YUAN Jin-Wei CHEN Xiao-Lan QU Ling-Bo ZHU Yu HUANG Xiao-Ying ZHAO Yu-Fen |
| Affiliation: | 1. Key Laboratory of Organic Chemistry and Chemical Biology of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou 450052,China 2. Key Laboratory of Organic Chemistry and Chemical Biology of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou 450052,China;Henan University of Technology,Zhengzhou,Henan Province 450052,China 3. Key Laboratory of Organic Chemistry and Chemical Biology of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou 450052,China;Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology,Ministry of Education,Department of Chemistry,School of Life Sciences and Engineering,Tsinghua University,Beijing 100084,China |
| Abstract: | 5,7-Dimethoxy-2-phenylquinolin-4-yl phenyloxy(N-L-alanine ethyl ester)phosphoramidate(C28H29N2O7P,Mr=536.17)has been synthesized by a facial phosphorylated reaction,and its structure was determined by IR,NMR,HR MS and X-ray single-crystal diffraction.The crystal belongs to triclinic,space group P-1,with a=11.375(2),b=11.591(2),c=11.638(2)(A),α=109.46(3),β=104.58(3),γ=100.48(3)°,V=1339.6(5)(A)3,Z=2,Dc=1.330 g/cm3,μ=0.152mm-1,F(000)=564,the final R=0.0654 and wR=0.1546.In the crystal structure,the title compound is constructed by a centrosymmetric dimmer unit composed of a pair of π-π stacking diastereoisomers.The compound has a noteworthy feature in the framework,and such units are linked by two equal intermolecular P=O…H-N hydrogen bonds. |
| Keywords: | synthesis 2-phenylquinolone phosphoramidate crystal structure |
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