Platinum(II) and palladium(II) complexes analogous to oxaliplatin with different cyclohexyldicarboxylate isomeric anions and their in vitro antitumour activity. Structural elucidation of [Pt(C2O4)(cis-dach)] |
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| Authors: | Al-Allaf Talal AK Rashan Luay J Steinborn Dirk Merzweiler Kurt Wagner Christoph |
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| Institution: | (1) Department of Chemistry, College of Basic Sciences, Applied Science University, Amman, 11931, Jordan;(2) Department of Pharmacology, College of Pharmacy, Applied Science University, Amman, 11931, Jordan;(3) Institut für Anorganische Chemie, Martin-Luther-Universität, Halle-Wittenberg, Kurt-Mothes-Strasse 2, D-06120 Halle, Germany |
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| Abstract: | Several new PtII and PdII complexes bearing the enantiomerically pure (1R,2R)-(–)-l,2-cyclohexanediamine (dach) ligand, of general formula MX2{(1R,2R)-dach}], where M = Pt or Pd, X2 = cis- or trans- or (1R,2R)-1,2-cyclohexyldicarboxylate anions, have been synthesized and characterized physicochemically and spectroscopically. These complexes have been screened in vitro against the three tumour cell lines K562, HeLa and L929, and the results obtained were compared with those of the reference standards, cisplatin, carboplatin and oxaliplatin; the known antitumour drugs. The single crystal X-ray structure determination of the Pt(C2O4)(cis-dach)] complex has been discussed and compared with that of oxaliplatin, Pt(C2O4){(1R,2R)-dach}]. |
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