Wittig-horner reaction of a phosphonate of reissert analogue a new method for introduction of alkyl groups into isoquinoline期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Wittig-horner reaction of a phosphonate of reissert analogue a new method for introduction of alkyl groups into isoquinoline

Authors:	Kin-ya Akiba Yoshio Negishi Katsuyuki Kurumaya Noboru Ueyama Naoki Inamoto

Institution:	Department of Chemistry, Faculty of Science, University of Tokyo Bunkyo-ku, Tokyo 113, Japan

Abstract:	Dimethyl 2-isopropoxycarbonyl-1, 2-dihydroisoquinoline-1-phosphonate ( $1$ ) was prepared from isoquinoline, isopropyl chloroformate, and trimethyl phosphite. Wittig-Horner reaction of $1$ with various aldehydes afforded the corresponding exo-methylene compounds, which were converted to 1-substituted isoquinolines with hydrogen chloride.

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