The preparation of octahydro leukotrienes C,D, and E via a stereoselective sulfenyllactonization reaction |
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| Authors: | Robert N Young William Coombs Yvan Guindon Joshua Rokach Diane Ethier Ronald Hall |
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| Institution: | Merck Frosst Laboratories, P.O. Box 1005, Pointe-Claire/Dorval, Quebec, Canada H9R 4P8 |
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| Abstract: | Sulfenyl halides derived from the N-trifluoroacetamido methyl ester derivatives of cysteine, cysteinyiglycine and glutathione react stereoselectively with (5E)- and (5Z)-eicosenoic acids to provide, after separation of diastereomers and hydrolysis of the protecting groups, the fully saturated analogues of leukotrienes LTC4, LTD4, and LTE4. |
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