| 4-肟醚基喹唑啉类化合物的合成及其抗植物病毒TMV活性 |
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| 引用本文： | 黄润秋,李慧英,马军安,邱德文. 4-肟醚基喹唑啉类化合物的合成及其抗植物病毒TMV活性[J]. 高等学校化学学报, 1996, 17(4): 571 |
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| 作者姓名： | 黄润秋 李慧英 马军安 邱德文 |
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| 作者单位： | 南开大学元素有机化学研究所, 元素有机化学国家重点实验室, 天津 300071 |
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| 摘 要： | 4-氯喹唑啉与取代芳香肟在碱存在下进行亲核取代反应,合成了17种新型肟醚基喹唑啉衍生物,并对其结构进行了表征。生物活性测试表明,部分化合物抗植物烟草花叶病毒活性超过抗植物病毒商品药剂2,4-二氧六氢-1,3,5-三嗪。
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| 关 键 词： | 喹唑啉 肟醚 抗植物病毒活性 |
| 收稿时间： | 1995-05-16 |
Synthesis of O-(4-Quinazolinyl)oxime Ethers and Their Antiviral Activity |
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| HUANG Run-Qiu,LI Hui-Ying, MA Jun-An,QIU De-Wen. Synthesis of O-(4-Quinazolinyl)oxime Ethers and Their Antiviral Activity[J]. Chemical Research In Chinese Universities, 1996, 17(4): 571 |
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| Authors: | HUANG Run-Qiu LI Hui-Ying MA Jun-An QIU De-Wen |
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| Affiliation: | Instiuted of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071 |
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| Abstract: | The O-(4quinazplinyl)oxime ethers compounds were synthesized by the reactionof 4-chloro quinazoline and substituted aryl oximes under a base.Their structures were confirmed by means of elementary analysis.IR,1H NMRand MS.The preliminary bioassayshows that some compounds have higher antiviral activity against TMV than 1,3,5-triazine-hexahvdro-2,4-dione(DHT);CompoundsⅠ6 and Ⅰ11, at～0.3 mmol/L, results in 60%and 65%inhibition of TMVin nicotiana tabacum leaves respectively, compared to 45% usingDHT,at 0.9mmol/L. |
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| Keywords: | Quinazoline Oxime-ether Antiviral activity |
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