| 乳化剂在双重乳液合成含胰岛素纳米胶囊中的作用 |
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| 引用本文： | 朱银燕,张高勇,洪昕林,董金凤,夏必来.乳化剂在双重乳液合成含胰岛素纳米胶囊中的作用[J].中国化学,2006,24(1):109-113. |
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| 作者姓名： | 朱银燕 张高勇 洪昕林 董金凤 夏必来 |
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| 作者单位： | [1]Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, China [2]China Research Institute of Daily Chemical Industry, Taiyuan, Shangxi 030001, China [3]Zhongshan Daqiao Chemical Industry Co. Ltd., Zhongshan, Guangzhou 528403, China |
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| 基金项目： | Project supported by the Key Project of the National Natural Science Founctation of China （No. 20233010）. |
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| 摘 要： | Insulin entrapped nanocapsules to use polylactide （PLA） as the encapsulating material were prepared through a modified water-in-oil-in-water （W/O/W） emulsification and solvent evaporation method, The average particle size of PLA nanocapsules obtained was decreased to （181.5 ± 8.4） nm, and capably adjusted from 180 to 370 nm by using different types and content of nonionic emulsifiers. The influence of emulsifiers on property of nanocapsules was discussed in detail. The effects of spans and tweens to modify the size of the nanocapsules were different, which can be due to the distribution of the surfactants on the inner interface between the inner water and oil of the double emulsion. The encapsulation efficiency and drug release of nanocapsules were affected obviously by the content and type of emulsifiers.
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| 关 键 词： | 乳化剂 胰岛素 合成方法 微胶囊 乳状液 |
| 收稿时间： | 2005-06-25 |
| 修稿时间： | 2005-06-252005-08-09 |
Influence of Emulsifiers on the Synthesis of Insulin-loaded Nanocapsules in Double Emulsion |
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| Zhu YinYan;Zhang GaoYong;Hong XinLin;Dong JinFeng;Xia BiLai.Influence of Emulsifiers on the Synthesis of Insulin-loaded Nanocapsules in Double Emulsion[J].Chinese Journal of Chemistry,2006,24(1):109-113. |
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| Authors: | Zhu YinYan;Zhang GaoYong;Hong XinLin;Dong JinFeng;Xia BiLai |
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| Abstract: | Insulin entrapped nanocapsules to use polylactide (PLA) as the encapsulating material were prepared through a modified water‐in‐oil‐in‐water (W/O/W) emulsification and solvent evaporation method. The average particle size of PLA nanocapsules obtained was decreased to (181.5±8.4) nm, and capably adjusted from 180 to 370 nm by using different types and content of nonionic emulsifiers. The influence of emulsifiers on property of nanocapsules was discussed in detail. The effects of spans and tweens to modify the size of the nanocapsules were different, which can be due to the distribution of the surfactants on the inner interface between the inner water and oil of the double emulsion. The encapsulation efficiency and drug release of nanocapsules were affected obviously by the content and type of emulsifiers. |
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| Keywords: | insulin nanocapsules double emulsion emulsifier polylactide |
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