| 具有生物活性的金属配合物的研究 II: 3,6-二(二甲氨基)-二苯并碘六环稀土乙二胺四乙酸配合物的合成, 性质及抗肿瘤活性 |
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| 引用本文： | 陈淑英,王初华,王欣,侯自杰,李笃,刘力生,宋家玉. 具有生物活性的金属配合物的研究 II: 3,6-二(二甲氨基)-二苯并碘六环稀土乙二胺四乙酸配合物的合成, 性质及抗肿瘤活性[J]. 化学学报, 1989, 47(4): 322-327 |
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| 作者姓名： | 陈淑英 王初华 王欣 侯自杰 李笃 刘力生 宋家玉 |
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| 作者单位： | 兰州大学化学系;兰州大学生物系 |
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| 摘 要： | 合成了十四种新的3,6-二(二甲氨基)-二苯并碘六环稀土乙二胺四乙酸(EDTA)配合物, 其化学式为[C17H20N2I][RE(EDTA)].xH2O(RE=Ce, x=2; Pr, x=3; Nd-Lu, Y,x=4). 利用热重-差热分析, X射线粉末衍射, 摩尔电导,红外及紫外光谱等对这些配合物进行了表征. 试验表明, 配合物对体外癌(L7712)细胞DNA合成的抑制率较其前体为高.
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| 关 键 词： | 紫外分光光度法 生物活性 抗癌药 红外分光光度法 Ｘ射线衍射分析 苯P 柠檬酸 ＥＤＴＡＰ 稀土金属络合物 金属络合物 |
Study on biologically active coordination compounds of metal ions II: Synthesis, characterization and antitumor activity of rare earth EDTA complexes of 3,6-bis(dimethylamino)-dibenzopyridonium |
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| CHEN SHUYING,WANG CHUHUA,WANG XIN,HOU ZIJIE,LI DU,LIU LISHENG,SONG JIAYU. Study on biologically active coordination compounds of metal ions II: Synthesis, characterization and antitumor activity of rare earth EDTA complexes of 3,6-bis(dimethylamino)-dibenzopyridonium[J]. Acta Chimica Sinica, 1989, 47(4): 322-327 |
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| Authors: | CHEN SHUYING WANG CHUHUA WANG XIN HOU ZIJIE LI DU LIU LISHENG SONG JIAYU |
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| Abstract: | Q[LnL].xH2O (Q+ = 3,6-bis(dimethylamino)dibenzopyriodonium; H4L = EDTA; Ln = Ce, x = 2; Ln = Pr, x = 3; Ln = Nd-Lu, Y, x = 4) were prepared The complexes were characterized by TG-DTA, x-ray powder diffraction, molar conductance, UV and IR spectra. The inhibiting effect of each complex on incorporation of 3H-TdR into DNA of leukemia (L7712) cells in vitro was observed The results show that they are all more effective than their precursors. |
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| Keywords: | ULTRAVIOLET SPECTROPHOTOMETRY BIOLOGICAL ACTIVITY ANTICARCINOGEN INFRARED SPECTROPHOTOMETRY X-RAY DIFFRACTION ANALYSIS BENZENE P CITRIC ACID EDTA P RARE EARTH METAL COMPLEX METAL COMPLEX |
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