| Vobasine-Aspidosperma型双吲哚生物碱的半合成 |
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| 引用本文： | 黄知恒,郑皎皎,周韵丽.Vobasine-Aspidosperma型双吲哚生物碱的半合成[J].化学学报,1989,47(9):884-889. |
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| 作者姓名： | 黄知恒 郑皎皎 周韵丽 |
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| 作者单位： | 中国科学院上海药物研究所 |
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| 摘 要： | Aspidosperma型生物碱与Vobasinol在酸性介质中偶合, 得到四个双吲哚生物碱,用^1HNMR与高分辨质谱推定了它们的结构, 各产物对肿瘤细胞生长有显著的抑制作用。
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| 关 键 词： | 抗癌药 质谱法 吲哚生物碱 质子磁共振谱法 合成法 |
Partial synthesis of vobasine-aspidosperma type bisindole alkaloids |
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| HUANG ZHIHENG,ZHENG JIAOJIAO,ZHOU YUNLI.Partial synthesis of vobasine-aspidosperma type bisindole alkaloids[J].Acta Chimica Sinica,1989,47(9):884-889. |
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| Authors: | HUANG ZHIHENG ZHENG JIAOJIAO ZHOU YUNLI |
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| Abstract: | Four vobasine-aspidosperma type bisindole alkaloids were prepared by coupling the monomeric counterparts in acidic medium and their structure confirmed by 1H NMR and MS. These new alkaloids, in particular I, showed remarkable antitumor activity to suppress the growth of P-388 cells in vitro. |
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| Keywords: | ANTICARCINOGEN MASS SPECTROGRAPHY INDOLE ALKALOIDS PROTON MAGNETIC RESONANCE SPECTROMETRY SYNTHESIS METHODS |
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