| Ph3P/CF3CCl3作为一个新的羰基烯烃化试剂的研究—一锅法合成烯烃RCH=CClCF3 |
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| 引用本文： | 李兴亚,傅伟敏,麻生明,蒋锡夔.Ph3P/CF3CCl3作为一个新的羰基烯烃化试剂的研究—一锅法合成烯烃RCH=CClCF3[J].化学学报,1989,47(4):360-366. |
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| 作者姓名： | 李兴亚 傅伟敏 麻生明 蒋锡夔 |
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| 作者单位： | 中国科学院上海有机化学研究所 |
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| 摘 要： | Ph3P/CF3CCl3与醛在室温下一锅反应生成三氟甲基取代的烯烃RCH=CClCF3(3). 芳香醛及α,β-不饱和醛的反应显示高度立体选择性, 给出Z式异构体. 而饱和脂肪醛的反应立体选择性较低, Z与E式异构体的比例为2:1至3:1. 反应可能是经由叶立德Ph3P-CClCF3的Wittig型反应. 本工作表明, Ph3P/CF3CCl3可以作为在十分温和的条件下向有机分子中引入=CClCF3结构单元的方便试剂.
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| 关 键 词： | 氯代烃 烯烃 维蒂希反应 三苯基膦 卤代烃 醛 氟代烃 化学试剂 羰基 乙烷P |
One pot synthesis of trifluoromethyl substituted olefins by using Ph3P/CF3CCl3 as a new carbonyl olefination reagents |
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| LI XINGYA,FU WEIMIN,MA SHENGMING,JIANG XIKUI.One pot synthesis of trifluoromethyl substituted olefins by using Ph3P/CF3CCl3 as a new carbonyl olefination reagents[J].Acta Chimica Sinica,1989,47(4):360-366. |
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| Authors: | LI XINGYA FU WEIMIN MA SHENGMING JIANG XIKUI |
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| Abstract: | A one-pot synthesis of trifluoromethyl olefins by reactions of Ph3P/CF3CCl3 with aldehydes at room temperature was reported. The reactions with aromatic and a,b-unsatd. aliphatic aldehydes are highly stereoselective and give Z isomers while the reactions with other aliphatic aldehydes give Z and E isomers in 2:1 to 3:1 ratios. |
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| Keywords: | CHLOROHYDROCARBON ALKENE WITTIG REACTION TRIPHENYLPHOSPHINE HALOHYDROCARBON ALDEHYDES FLUOROHYDROCARBON CHEMICAL REAGENT CARBONYL GROUP ETHANE P |
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