| 具有生物活性的金属配合物的研究 III: 3-6(二(二甲氨基)-二苯并碘六环稀土二柠檬酸配合物的合成, 性质及抗肿瘤活性 |
| |
| 引用本文： | 陈淑英,王初华,侯自杰,李笃,刘力生,宋家玉. 具有生物活性的金属配合物的研究 III: 3-6(二(二甲氨基)-二苯并碘六环稀土二柠檬酸配合物的合成, 性质及抗肿瘤活性[J]. 化学学报, 1989, 47(4): 328-332 |
| |
| 作者姓名： | 陈淑英 王初华 侯自杰 李笃 刘力生 宋家玉 |
| |
| 作者单位： | 兰州大学化学系;兰州大学生物系 |
| |
| 摘 要： | 合成了十五种新的3,6-二(二甲氨基)-二苯并碘六环稀土二柠檬酸配合物, 其化学式为: [C17H20N2I]3[RE(C6H5O7)2].xH2O(RE=La-Nd, x=5; Sm-Tb, x=4; Dy-Lu, Y,x=3). 利用X射线粉末衍射、热重-差热, 红外光谱、紫外光谱、摩尔电导等对这些配合物进行了表征. 试验表明, 镧配合物对L7712癌细胞DNA合成的抑制率(97.3%)明显高于其前体(C17H20N2I^+.HCOO^-, 72.5%; Na3[La(C6H5O7)2], -16.5%.
|
| 关 键 词： | 紫外分光光度法 生物活性 抗癌药 红外分光光度法 Ｘ射线衍射分析 苯P 柠檬酸 稀土金属络合物 铈络合物 差热分析 |
Study on biologically active coordination compounds of metal ions III: Synthesis, characterization and antitumor activity of rare earths citrate complexes of 3,6-bis(dimethylamino)-dibenzopyriodonium |
| |
| CHEN SHUYING,WANG CHUHUA,HOU ZIJIE,LI DU,LIU LISHENG,SONG JIAYU. Study on biologically active coordination compounds of metal ions III: Synthesis, characterization and antitumor activity of rare earths citrate complexes of 3,6-bis(dimethylamino)-dibenzopyriodonium[J]. Acta Chimica Sinica, 1989, 47(4): 328-332 |
| |
| Authors: | CHEN SHUYING WANG CHUHUA HOU ZIJIE LI DU LIU LISHENG SONG JIAYU |
| |
| Abstract: | L3[LnQ2].nH2O (L+ = 3,6-bis(dimethylamino)benzopyriodonium; H3Q = citric acid; Ln = La-Nd, n = 5; Ln = Sm-Tb, n = 4; Ln = Dy-Lu, Y, n = 3) were prepared The complexes were characterized by x-ray powder diffraction, TG-DTA, molar conductances, IR, UV and 1H NMR. Inhibiting effect of La complex on incorporation of 3H-TdR into DNA of leukemia (L7712) cells in vitro was observed The results show that La complex is more effective than its precursors. |
| |
| Keywords: | ULTRAVIOLET SPECTROPHOTOMETRY BIOLOGICAL ACTIVITY ANTICARCINOGEN INFRARED SPECTROPHOTOMETRY X-RAY DIFFRACTION ANALYSIS BENZENE P CITRIC ACID RARE EARTH METAL COMPLEX CERIUM COMPLEX DIFFERENTIAL THERMAL ANALYSIS |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《化学学报》浏览原始摘要信息 |
|
点击此处可从《化学学报》下载全文 |
|
