| 抗癌药顺铂对照品制备及其纯度测定 |
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| 引用本文： | 谌喜珠,刘洋,刘伟平.抗癌药顺铂对照品制备及其纯度测定[J].分析试验室,2008,27(2):46-47. |
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| 作者姓名： | 谌喜珠 刘洋 刘伟平 |
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| 作者单位： | 昆明贵金属研究所贵金属药物研究室,昆明,650221 |
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| 基金项目： | 云南省院所技术开发专项(2004KFX)项目资助 |
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| 摘 要： | 提出了抗癌药顺铂对照品的新制备方法并进行其纯度测定。该方法涉及在二甲基甲酰胺中用18-冠醚-6选择沉淀trans-Pt(NH3)2Cl2],然后用NaCl溶液反析顺铂、分离KPt(NH3)Cl3]。采用HPLC和TLC法测定制备出的顺铂。结果表明所制备的顺铂纯度大于99.5%,有关杂质均小于0.1%,满足作为对照品的要求。
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| 关 键 词： | 顺铂 对照品 制备 |
| 文章编号： | 1000-0720（2008）02-046-02 |
| 收稿时间： | 2006-01-03 |
| 修稿时间： | 2006-10-21 |
Preparation and purity determination of cisplatin used for a reference standard |
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| CHEN Xi-zhu,LIU Yang,LIU Wei-ping.Preparation and purity determination of cisplatin used for a reference standard[J].Chinese Journal of Analysis Laboratory,2008,27(2):46-47. |
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| Authors: | CHEN Xi-zhu LIU Yang LIU Wei-ping |
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| Abstract: | A new technique was introduced to prepare high-purity cisplatin.The technique involves selective separation of trans-Pt(NH3)2Cl2]I in DMF with 18-crown-6,followed by re-precipitation of cisplatin with sodium chloride solution.The purity of the product was determined by HPLC and TLC.The results showed that the content of Cisplatin so prepared was greater than 99.5% and single related impurity did not exceed 0.1%,meeting the reqirement as a reference standard. |
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| Keywords: | Cisplatin Reference standard Preparation Analysis |
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