A new polymer-supported reagent for the synthesis of beta-lactams in solution |
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Authors: | Donati Donato Morelli Costanza Porcheddu Andrea Taddei Maurizio |
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Institution: | Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy. |
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Abstract: | A modified Mukaiyama reagent was prepared on a PS-DVB resin. This reagent was used for the preparation of beta-lactams, using the Staudinger reaction. The products were obtained by generating the ketene from a carboxylic acid under sonication with the resin followed by reaction with the imine. Excess of the imine was removed by reduction followed by acid scavenging. |
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