Algal transformation of hydrocortisone by the cyanobacterium Nostoc ellipsosporum |
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| Authors: | Y Ghasemi M Tabatabaei Yazdi A Dehshahri H Niknahad S Shokravi M Amini A Ghasemian M A Faramarzi |
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| Institution: | (1) Department of Pharmacognosy, Faculty of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran;(2) Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran;(3) Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran;(4) Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, 14174, Iran;(5) Department of Biology, Institute of Applied Sciences, Iranian Center of Culture and Education, Shahid Beheshti University, P.O. Box 19835-371, Tehran, Iran |
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| Abstract: | The potential of Nostoc ellipsosporum for biotransformation of hydrocortisone was studied. The microorganism was isolated during a screening program from soil
samples collected from the paddy fields in the north of Iran and had not been previously examined for this purpose. The biotransformation
yielded 11β,17α,20β, 21-tetrahydroxypregn-4-en-3-one and 11β-hydroxyandrost-4-ene-3,17-dione. Both of the metabolites were purified chromatographically and characterized using instrumental
analyses.
Published in Khimiya Prirodnykh Soedinenii, No. 6, pp. 572–574, November–December, 2006. |
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| Keywords: | Biotransformation hydrocortisone microalgae Nostoc ellipsosporum |
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