Novel and anti-inflammatory constituents of Garcinia subelliptica |
| |
Authors: | Weng Jing-Ru Lin Chun-Nan Tsao Lo-Ti Wang Jih-Pyang |
| |
Institution: | School of Pharmacy, Kaohsiung Medical University Kaohsiung, Taiwan 807, Republic of China. lincna@cc.kmu.edu.tw |
| |
Abstract: | Four novel phloroglucinol derivatives, garcinielliptones A (1), B (2), C (3), D (4), a novel triterpenoid, garcinielliptone E (5), and three known compounds were isolated from the seeds of Garcinia subelliptica. The structures, including relative configurations, were elucidated by means of spectroscopic data. Known compounds garsubellin A (6) and garcinielliptin oxide (7) showed potent inhibitory effects on the release of beta-glucuronidase, and beta-glucuronidase and histamine, respectively, from peritoneal mast cells stimulated with compound 48/80 in a concentration-dependent manner with IC(50) values of 15.6+/-2.5, and 18.2+/-3.6 and 20.0+/-2.7 microM, respectively. Compound 7 showed potent inhibitory effects on the release of beta-glucuronidase and lysozyme from neutrophils stimulated with formyl-Met-Leu-Phe(fMLP)/cytochalasin B (CB) in a concentration-dependent manner with IC(50) values of 15.7+/-3.0 and 23.9+/-3.2 microM, respectively. Compound 7 also showed potent inhibitory effect on superoxide formation from neutrophils stimulated with fMLP/CB also in a concentration-dependent manner with an IC(50) value of 17.9+/-1.5 microM. |
| |
Keywords: | anti‐inflammatory activity Garcinia subelliptica NMR spectroscopy phloroglucinol derivatives terpenoids |
本文献已被 PubMed 等数据库收录! |
|