| 1-（N-（2-（2-Methoxyphenylthio）benzyl）-N-methylamino-3-aryloxypropan-2-ols： Synthesis and evaluation for dual 5-HT1A/SSRI activities |
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| 作者姓名： | Xin Wang Dong Zhi Liu Ai Jun Li |
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| 作者单位： | a School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;b School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China |
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| 摘 要： | A series of 1-（N-（2-（2-methoxyphenylthio）benzyl）-N-methylamino-3-aryloxypropan-2-ols derivatives were designed and synthesized based on 5-HT1A/SSRI drugs design strategies. The synthesized compounds were evaluated for their dual 5-HT1A/ 5-HTT activities. 2007 Ai Jun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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| 关 键 词： | 抗抑郁药 药物合成 杀螨好 5-羟色胺 |
| 收稿时间： | 29 August 2007 |
1-(N-(2-(2-Methoxyphenylthio)benzyl)-N-methylamino-3-aryloxypropan-2-ols: Synthesis and evaluation for dual 5-HT1A/SSRI activities |
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| Xin Wang Dong Zhi Liu Ai Jun Li.1-(N-(2-(2-Methoxyphenylthio)benzyl)-N-methylamino-3-aryloxypropan-2-ols: Synthesis and evaluation for dual 5-HT1A/SSRI activities[J].Chinese Chemical Letters,2008,19(1):40-42. |
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| Authors: | Xin Wang Dong Zhi Liu Ai Jun Li |
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| Institution: | a School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;b School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China |
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| Abstract: | A series of 1-(N-(2-(2-methoxypbenylthio)benzyl)-N-methylamino-3-aryloxypropan-2-ols derivatives were designed andsynthesized based on 5-HT1A/SSRI drugs design strategies. The synthesized compounds were evaluated for their dual 5-HT1A/5-HTI" activities. |
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| Keywords: | 5-HT1A/SSRI Serotonin transporter 5-HT1A receptor Diphenylsulfide |
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