Bartoli indole synthesis on solid supports |
| |
Authors: | Knepper Kerstin Bräse Stefan |
| |
Affiliation: | Kekulé-Institut für Organische Chemie and Biochemie der Rheinischen Friedrich-Wilhelms-Universit?t Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany. |
| |
Abstract: | [reaction: see text] Bartoli indole synthesis has been performed for the first time on solid supports. Starting from Merrifield resin, immobilization of five nitro benzoic acids was performed. Addition of four different alkenyl Grignard reagents and basic cleavage leads to substituted methyl indole carboxylates in excellent purities. Features of this reaction are the stability of halide groups, ester moieties, and tolerance of o,o'-unsubstituted nitro resins. Heck and Sonogashira reactions are also possible with immobilized indoles. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|