Dioscorealides and dioscoreanone,novel cytotoxic naphthofuranoxepins,and 1,4-phenanthraquinone from Dioscorea membranacea Pierre |
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Authors: | Itharat Arunporn Plubrukarn Anuchit Kongsaeree Palangpon Bui Tam Keawpradub Niwat Houghton Peter J |
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Institution: | Pharmacognosy Research Laboratories, Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford St., London SEI 8WA, UK. |
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Abstract: | structure: see text] Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here. |
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