This paper is concerned with the following fourth-order elliptic equation
$$\begin{aligned} \left\{ \begin{array}{ll} \displaystyle \Delta ^{2}u-\Delta u+V(x)u=|u|^{p-1}u,\,\mathrm{in}\,\mathbb {R}^{N},\\ u\in H^{2}\left( \mathbb {R}^{N}\right) , \end{array} \right. \end{aligned}$$
where
\(p\in (2,\,2_{*}-1),\,u{\text {:}}\,\mathbb {R}^{N}\rightarrow \mathbb R.\) Under some appropriate assumptions on potential
V(
x), the existence of nontrivial solutions and the least energy nodal solution are obtained by using variational methods.