| Studies on Mechanisms and Blockade of Carcinogenic Action of Female Sex Hormones |
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| 作者姓名： | 高凤鸣 蒋涵英 余璐 李新兰 王文惠 段云波 周红宁 |
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| 作者单位： | Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC，Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC，Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC，Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC，Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC，Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC，Laboratory of Industrial Hygiene，Ministry of Public Health，Beijing 100088，PRC |
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| 基金项目： | Project supported in part by the Bureau of Science and Education,Ministry of Public Health,PRC. |
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| 摘 要： | Tumours of mice are induced by administration of Inj. Hydroxyprogesteroni Caproatis Co. (EP) in a practical subthreshold dose of carcinogenesis or 2. 5-5 times the human contraceptive dose (simply referred to as 2. 5- to 5-fold dose) combined with whole-body 0. 5 Gy gamma-ray irradiation. Malignant transformation of Syrian golden hamster embryo (SHE) cells is also induced by 5-fold dose of EP combined with 0. 3 Gy gamma-ray irradiation in vitro, thereby indicating that synergistic carcinogenesis can be obtained by combined use of physical and chemical carcinogens.The mechanisms of synergistic carcinogenesis have been further explained by cytogenetics, damage extent of the target cell DNA and production of free radicals. The Chinese traditional medicine with antioxidat-ing effect (Sulekang Capsule, SC), food additive--butylated hydroxyanisole (BHA) and green tea can effectively inhibit the carcinogenic effect of EP or EP combined with gamma rays in mice. They all have marked ability to scavenge or remove
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Studies on Mechanisms and Blockade of Carcinogenic Action of Female Sex Hormones |
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| GAO Feng-Ming,JIANG Han-Ying,YU LuLI Xin-Lan,WANG Wen-Hui,DUAN Yun-Boand ZHOU Hong-Ning.Studies on Mechanisms and Blockade of Carcinogenic Action of Female Sex Hormones[J].Science in China(Chemistry),1994(4). |
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| Authors: | GAO Feng-Ming JIANG Han-Ying YU LuLI Xin-Lan WANG Wen-Hui DUAN Yun-Boand ZHOU Hong-Ning |
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| Abstract: | Tumours of mice are induced by administration of Inj. Hydroxyprogesteroni Caproatis Co. (EP) in a practical subthreshold dose of carcinogenesis or 2. 5-5 times the human contraceptive dose (simply referred to as 2. 5- to 5-fold dose) combined with whole-body 0. 5 Gy gamma-ray irradiation. Malignant transformation of Syrian golden hamster embryo (SHE) cells is also induced by 5-fold dose of EP combined with 0. 3 Gy gamma-ray irradiation in vitro, thereby indicating that synergistic carcinogenesis can be obtained by combined use of physical and chemical carcinogens.The mechanisms of synergistic carcinogenesis have been further explained by cytogenetics, damage extent of the target cell DNA and production of free radicals. The Chinese traditional medicine with antioxidat-ing effect (Sulekang Capsule, SC), food additive--butylated hydroxyanisole (BHA) and green tea can effectively inhibit the carcinogenic effect of EP or EP combined with gamma rays in mice. They all have marked ability to scavenge or remove the free radicals and thereby reduce the DNA damage. |
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| Keywords: | female sex hormones gamma rays carcinogenesis green tea free radicals |
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