| Preparation and Characterization of Biodegradable Polylactide（PLA） Microspheres Encapsulating Ginsenoside Rg3 |
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| 作者姓名： | LIU Cheng-bai ZHANG Di LI De-guan JIANG Dan CHEN Xia |
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| 作者单位： | College of Life Science, Jilin University, Changchun 130021, P. R. China |
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| 摘 要： | In this study, the process of a biodegradable polylactide（PLA） microsphere encapsulating ginsenoside Rg3 was first studied by the emulsion solvent evaporation method, for enhancing solubility and stability of ginsenoside Rg3. Alabum was also first used as a modifier in this method. The mean diameter of the prepared PLA microspheres containing Rg3 was 40 μm. Ginsenoside Rg3 released from the microspheres was studied by HPLC and detected by UV. It was found that the drug release curve fitted the Model Heller-Baker best.
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| 关 键 词： | 人参Rg3 受控释放 药物病理学 微粒子 |
| 收稿时间： | 5 December 2007 |
Preparation and Characterization of Biodegradable Polylactide(PLA) Microspheres Encapsulating Ginsenoside Rg3 |
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| LIU Cheng-bai ZHANG Di LI De-guan JIANG Dan CHEN Xia.Preparation and Characterization of Biodegradable Polylactide(PLA) Microspheres Encapsulating Ginsenoside Rg3[J].Chemical Research in Chinese University,2008,24(5):588-591. |
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| Authors: | LIU Cheng-bai ZHANG Di LI De-guan JIANG Dan CHEN Xia College of Life Science Jilin University Changchun P R China |
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| Institution: | LIU Cheng-bai,ZHANG Di,LI De-guan,JIANG Dan , CHEN Xia College of Life Science,Jilin University,Changchun 130021,P. R. China |
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| Abstract: | In this study,the process of a biodegradable polylactide(PLA) microsphere encapsulating ginsenoside Rg3 was first studied by the emulsion solvent evaporation method,for enhancing solubility and stability of ginsenoside Rg3.Alabum was also first used as a modifier in this method.The mean diameter of the prepared PLA microspheres containing Rg3 was 40 μm.Ginsenoside Rg3 released from the microspheres was studied by HPLC and detected by UV.It was found that the drug release curve fitted the Model Heller-Baker best. |
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| Keywords: | Microparticle Ginsenoside Rg3 PLA Controlled release |
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